Post-mortem evidence of idiopathic left ventricular hypertrophy and idiopathic interstitial myocardial fibrosis: is exercise the cause?
Why the study?
Does life-long arduous physical activity cause idiopathic left ventricular hypertrophy and interstitial myocardial fibrosis leading to fatal arrhythmias in marathon runners?
Population
1 experienced, highly trained marathon runner who died suddenly while running
Design
Case_report
Authors
Discussion
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Member takes
Implication
May suggest exercise-related fibrosis as arrhythmia substrate in runners; hypothesis-generating and should not alter activity guidance.
Structured PICO
Does life-long arduous physical activity cause idiopathic left ventricular hypertrophy and interstitial myocardial fibrosis leading to fatal arrhythmias in marathon runners?
P
Population
1 experienced, highly trained marathon runner who died suddenly while running
I
Intervention
Life-long, repetitive bouts of arduous physical activity (marathon running)
O
Outcome
Post-mortem findings of left ventricle hypertrophy and idiopathic interstitial myocardial fibrosis
Life-long arduous physical activity may lead to fibrous replacement of the myocardium, creating a pathological substrate for fatal arrhythmias.
Cite This Study
Whyte et al. (2009) studied this question.