Why the study?
Despite known hemodynamic effects of propofol and remifentanil, comprehensive quantitative analyses in surgical settings considering noxious stimuli were lacking.
How do propofol, remifentanil, and noxious stimulation interact to affect mean arterial pressure and heart rate in female patients undergoing gynecology surgery?
Population
77 female ASA I-II patients undergoing gynecology surgery
Comparison
Different administration schemes and effect-site concentrations of propofol and remifentanil with noxious stimuli
Design
Prospective pharmacodynamic modeling study
Authors
Loading...
May heighten hypotension vigilance during propofol-remifentanil induction/emergence in gynecology; extends PD modeling but remains hypothesis-generating.
How do propofol, remifentanil, and noxious stimulation interact to affect mean arterial pressure and heart rate in female patients undergoing gynecology surgery?
A semi-mechanistic pharmacodynamic model characterizes the hemodynamic effects of propofol and remifentanil during gynecology surgery, highlighting a significant risk of hypotension during induction and emergence.
Garraza-Obaldia et al. (2024) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: