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January 1, 2023Journal of Vascular Research

Tortuosity and Proximal-Specific Hemodynamics Associated with Plaque Location in the Carotid Bulb Stenosis

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Why the study?

Carotid bulb plaque locations correlate with ischemic lesion patterns and progression, but the complex mechanisms governing plaque formation and location remain unclear.

Are geometric and hemodynamic parameters associated with plaque location in patients with carotid bulb stenosis?

Comparison

Body plaques vs apical plaques

Design

Retrospective observational study

Authors

LRLei RenFirst Teaching Hospital of Tianjin University of Traditional Chinese MedicineRXRongjie XuTongji UniversityCZChenxi ZhaoNanjing University of Information Science and Technology

Discussion

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Implication

Should not yet change carotid stenosis evaluation; extends observational links between geometry, hemodynamics, and plaque sites.

Structured PICO

Are geometric and hemodynamic parameters associated with plaque location in patients with carotid bulb stenosis?

P
Population
70 consecutive patients with single carotid bulb stenosis (50-99%)
I
Intervention
High-resolution vessel wall magnetic resonance imaging and computational fluid dynamics simulations
C
Comparator
Comparison between body plaque (n=41) and apical plaque (n=29) locations
O
Outcome
Plaque characteristics, geometric parameters, and hemodynamic parameters (including wall shear stress) associated with plaque locationsurrogate

Tortuosity and proximal-specific hemodynamics, including wall shear stress, are significantly associated with the location of atherosclerotic plaques in the carotid bulb.

Cite This Study

Ren et al. (2023) studied this question.

synapsesocial.com/papers/6a1cc2cd566b67b7d585e13bhttps://doi.org/10.1159/000531584
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Carotid Plaque Vulnerability2011 · 111 citations
  2. 2The Study on Hemodynamic Effect of Varied Support Models of BJUT-II VAD on Coronary Artery2014 · 18 citations
  3. 3Association Between Carotid Bifurcation Geometry and Atherosclerotic Plaque Vulnerability2020 · 44 citations
  4. 4Atherosclerotic Carotid Stenoses of Apical versus Body Lesions in High-Risk Carotid Stenting Patients2010 · 36 citations
  5. 5Carotid Bifurcation Geometry Is an Independent Predictor of Early Wall Thickening at the Carotid Bulb2013 · 80 citations