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December 20, 2013StrokeOpen Access

Carotid Bifurcation Geometry Is an Independent Predictor of Early Wall Thickening at the Carotid Bulb

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Why the study?

Does carotid bifurcation geometry predict early wall thickening at the carotid bulb?

Population

Subsets of the Atherosclerosis Risk in Communities Carotid MRI study: Group 1 nonstenotic cases with…

Design

Cohort

Authors

PBPayam B. BijariUniversity of TorontoBWBruce A. WassermanCardiac ImagingDSDavid A. SteinmanCardiac Imaging

Discussion

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Implication

Should not yet change practice; supports geometric risk hypothesis but remains hypothesis-generating.

Structured PICO

Does carotid bifurcation geometry predict early wall thickening at the carotid bulb?

P
Population
Subsets of the Atherosclerosis Risk in Communities (ARIC) Carotid MRI study: Group 1 (n=467) nonstenotic cases with sufficient quality angiography; Group 2 (n=346) excluding cases with wall thickness above inward remodeling thresholds; Group 3 (n=294) excluding cases with lumen irregularities.
I
Intervention
Carotid bifurcation geometry assessment (bifurcation flare and proximal curvature)
O
Outcome
Internal carotid artery wall thicknesssurrogate

Carotid bifurcation geometry is an independent predictor of early wall thickening, supporting the geometric risk hypothesis for atherosclerosis when confounding effects of disease on geometry are accounted for.

Cite This Study

Bijari et al. (2013) studied this question.

synapsesocial.com/papers/6a80a2c82ea91e47663d6a3dhttps://doi.org/10.1161/strokeaha.113.003454
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Geometric factors of the bifurcation in carotid atherogenesis.1990 · 82 citations
  2. 2Variation in the Carotid Bifurcation Geometry of Young Versus Older Adults2005 · 246 citations
  3. 3Internal Carotid Artery Angle of Origin2003 · 96 citations
  4. 4Patterns of Atherosclerosis and their Surgical Significance1985 · 349 citations
  5. 5Pulsatile flow and atherosclerosis in the human carotid bifurcation. Positive correlation between plaque location and low oscillating shear stress.1985 · 2,719 citations