Key result
Higher baseline carotid tortuosity independently predicted a regression in carotid wall thickness at 12 months (regression coefficient -0.52) in high-risk patients.
Why the study?
Carotid geometry and wall shear stress have been proposed as independent risk factors for carotid atherosclerosis progression, but this had not been demonstrated in larger longitudinal studies.
Do baseline carotid geometry and wall shear stress predict changes in carotid wall thickness at 12 months in high-risk patients with carotid plaques?
Population
97 consecutive high-risk hypertensive patients with ICA plaques
Comparison
Baseline carotid geometry and hemodynamics assessed for changes in wall thickness
Design
Prospective longitudinal cohort study
Follow-up
12 months
Authors
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Association in high-risk hypertension patients remains hypothesis-generating; larger prospective studies needed to confirm progression link.
Cohort (n=97)
No
Do baseline carotid geometry and wall shear stress predict changes in carotid wall thickness at 12 months in high-risk patients with carotid plaques?
Effect estimate: regression coefficient -0.52 (95% CI -0.76 to -0.28)
p-value: p=<0.001
A large ICA bulb, large bifurcation angle, and low wall shear stress independently predict the progression of carotid atherosclerosis in patients without significant ICA stenosis.
Strecker et al. (2021) conducted a cohort in High cardiovascular risk with internal carotid artery plaques (n=97). Carotid geometry and wall shear stress was evaluated on Change in carotid wall thickness at 12 months (association with baseline tortuosity) (regression coefficient -0.52, 95% CI -0.76 to -0.28, p=<0.001). Higher baseline carotid tortuosity independently predicted a regression in carotid wall thickness at 12 months (regression coefficient -0.52) in high-risk patients.
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