Key result
High-risk carotid plaques exhibited significantly higher wall shear stress compared to low-risk plaques throughout the cardiac cycle (p < 0.05), particularly in the axial direction and during diastole.
Why the study?
Differences in wall shear stress across plaque risk levels, time points, and directions in patients with moderate carotid artery stenosis remained unclear.
Does wall shear stress differ between high-risk and low-risk plaques in patients with moderate carotid artery stenosis?
Design
Cross-sectional 4D flow MRI imaging study
Authors
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Higher WSS in high-risk plaques may aid stratification in moderate stenosis; leaves open prospective validation before clinical use.
Cross-Sectional (n=30)
No
Does wall shear stress differ between high-risk and low-risk plaques in patients with moderate carotid artery stenosis?
p-value: p=<0.05
Increased wall shear stress, particularly in the axial direction and during diastole, is associated with high-risk plaque features in patients with moderate carotid artery stenosis.
Zhang et al. (2021) conducted a cross-sectional in Moderate carotid artery stenosis (n=30). High-risk plaque vs. Low-risk plaque was evaluated on Wall shear stress (WSS) (p=<0.05). High-risk carotid plaques exhibited significantly higher wall shear stress compared to low-risk plaques throughout the cardiac cycle (p < 0.05), particularly in the axial direction and during diastole.
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