Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
August 11, 2021Frontiers in NeuroscienceOpen Access

Differences in Wall Shear Stress Between High-Risk and Low-Risk Plaques in Patients With Moderate Carotid Artery Stenosis: A 4D Flow MRI Study

View Full Paper
Ask AI
Bookmark
Share

Key result

High-risk carotid plaques exhibited significantly higher wall shear stress compared to low-risk plaques throughout the cardiac cycle (p < 0.05), particularly in the axial direction and during diastole.

Why the study?

Differences in wall shear stress across plaque risk levels, time points, and directions in patients with moderate carotid artery stenosis remained unclear.

Does wall shear stress differ between high-risk and low-risk plaques in patients with moderate carotid artery stenosis?

Design

Cross-sectional 4D flow MRI imaging study

Authors

GZGuiling ZhangTongji HospitalSZShun ZhangTongji HospitalYQYuanyuan QinGuangxi University

Discussion

Loading...

Member takes

Overview

Higher WSS in high-risk plaques may aid stratification in moderate stenosis; leaves open prospective validation before clinical use.

Study Design

Type

Cross-Sectional (n=30)

Multicenter

No

Structured PICO

Does wall shear stress differ between high-risk and low-risk plaques in patients with moderate carotid artery stenosis?

P
Population
30 patients (mean age 56.3 years, 33.3% female) with moderate carotid artery stenosis (30-70%) contributing 40 carotid arteries for evaluation of plaque risk.
E
Exposure
High-risk plaques (defined by high-resolution vessel wall imaging showing high-risk characteristics and cerebrovascular events on DWI)
C
Comparator
Low-risk plaques (defined by no high-risk components on imaging and no cerebrovascular events)
O
Outcome
Difference in wall shear stress (WSS) (axial, circumferential, and 3D) between high-risk and low-risk plaques across the cardiac cyclesurrogate

Main Result

p-value: p=<0.05

Increased wall shear stress, particularly in the axial direction and during diastole, is associated with high-risk plaque features in patients with moderate carotid artery stenosis.

Limitations

  • Strict criteria for high-risk plaques requiring both imaging results and cerebrovascular events may limit clinical applicability
  • Geometries and multi-slice/multi-segment models of the carotid arteries were not investigated
  • Small sample size requiring further verification in larger datasets
  • Stricter criteria for high-risk plaques than used in clinic (requiring both imaging signs and cerebrovascular events)
  • Small sample size

Cite This Study

Zhang et al. (2021) conducted a cross-sectional in Moderate carotid artery stenosis (n=30). High-risk plaque vs. Low-risk plaque was evaluated on Wall shear stress (WSS) (p=<0.05). High-risk carotid plaques exhibited significantly higher wall shear stress compared to low-risk plaques throughout the cardiac cycle (p < 0.05), particularly in the axial direction and during diastole.

synapsesocial.com/papers/6a40667baf768a5aebd70c92https://doi.org/10.3389/fnins.2021.678358
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Comparison of stable carotid plaques in patients with mild-to-moderate carotid stenosis with vulnerable plaques in patients with significant carotid stenosis2024 · 4 citations
  2. 2Wall shear stress calculations based on 3D cine phase contrast MRI and computational fluid dynamics: a comparison study in healthy carotid arteries2014 · 80 citations
  3. 3Non-invasive assessment of intracranial wall shear stress using high-resolution magnetic resonance imaging in combination with computational fluid dynamics technique2021 · 13 citations
  4. 4Exploring the risk stratification of carotid plaque hemodynamic using four-dimensional blood flow technology2026
  5. 5Exploring the Relationships Between Hemodynamic Stresses in the Carotid Arteries2021 · 14 citations