Key result
Vulnerable carotid plaques are linked to ~36% lower downstream wall shear stress than stable plaques.
Why the study?
The study was conducted to compare characteristics of stable and vulnerable carotid plaques and evaluate the diagnostic performance of wall shear stress based on magnetic resonance plaque imaging.
Do wall shear stress parameters differ between stable carotid plaques with mild-to-moderate stenosis and vulnerable plaques with significant stenosis?
Population
64 atherosclerotic plaques
Comparison
Vulnerable plaques with significant stenosis vs stable plaques with mild-to-moderate stenosis
Design
Retrospective observational study
Authors
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WSS metrics may help identify vulnerable carotid plaques on MR imaging; hypothesis-generating in retrospective data and requires prospective validation.
Observational (n=64)
Do wall shear stress parameters differ between stable carotid plaques with mild-to-moderate stenosis and vulnerable plaques with significant stenosis?
Effect estimate: AUC 0.96 (95% CI 0.79-1.14)
Absolute Event Rate: 2.88% vs 4.47%
p-value: p=.003
Vulnerable carotid plaques with significant stenosis exhibit significantly lower wall shear stress compared to stable plaques, with downstream WSS offering high diagnostic accuracy.
Liu et al. (2024) conducted an observational in Carotid stenosis (n=64). Vulnerable carotid plaques with significant stenosis vs. Stable carotid plaques with mild-to-moderate stenosis was evaluated on Downstream wall shear stress (WSSdown) (AUC 0.96, 95% CI 0.79-1.14, p=.003). Vulnerable carotid plaques with significant stenosis had significantly lower downstream wall shear stress than stable plaques (2.88 vs 4.47 Pa, P=0.003), with an AUC of 0.96 for discrimination.
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