Key result
Low wall shear stress was associated with middle cerebral artery atherosclerosis formation, with lower WSS ratios in atherosclerotic MCAs compared to normal MCAs (p=0.002).
Why the study?
In vivo studies on the association between wall shear stress and intracranial plaque were deficient.
Is low wall shear stress assessed by HR-MRI and CFD associated with intracranial plaque location in the middle cerebral artery?
Population
43 patients with low-grade stenotic (<50%) atherosclerotic MCA (94 plaques) and 50 normal MCAs
Comparison
Atherosclerotic MCAs vs normal MCAs
Design
Observational imaging and computational fluid dynamics study
Authors
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Hypothesis-generating for low WSS in MCA atherosclerosis; prospective studies needed before clinical consideration.
Observational (n=93)
Is low wall shear stress assessed by HR-MRI and CFD associated with intracranial plaque location in the middle cerebral artery?
p-value: p=0.002
Low wall shear stress assessed by a novel HR-MRI and CFD model is associated with middle cerebral artery atherosclerosis formation, supporting the low WSS theory.
Chen et al. (2021) conducted an observational in Middle cerebral artery atherosclerosis (n=93). Low wall shear stress (WSS) vs. Normal MCAs was evaluated on WSS ratio of the ventral-inferior wall to the dorsal-superior wall and WSS inner-outer ratio (p=0.002). Low wall shear stress was associated with middle cerebral artery atherosclerosis formation, with lower WSS ratios in atherosclerotic MCAs compared to normal MCAs (p=0.002).
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