Why the study?
Although wall shear stress and pressure play important roles in plaque vulnerability, characteristics of these two indices in intracranial atherosclerosis have not been fully investigated.
Does a TOF-MRA-based computational fluid dynamics model reveal correlations between wall shear stress, pressure drop, and percent stenosis in symptomatic intracranial atherosclerosis?
Population
Subjects with symptomatic ICAS in middle cerebral artery domain (fifty-five atherosclerotic lesions analyzed)
Comparison
Noninvasive computational fluid dynamics modeling of 3D hemodynamics
Design
Pilot study
Authors
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Supports CFD modeling of intracranial stenosis hemodynamics; leaves open whether WSS or pressure metrics improve stroke risk stratification.
Does a TOF-MRA-based computational fluid dynamics model reveal correlations between wall shear stress, pressure drop, and percent stenosis in symptomatic intracranial atherosclerosis?
A TOF-MRA-based CFD model demonstrates that wall shear stress and pressure drop increase significantly in intracranial atherosclerosis when stenosis exceeds 50%, highlighting the potential of non-invasive hemodynamic assessment for stroke risk evaluation.
Chen et al. (2020) studied this question.
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