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March 16, 1957Journal of the American Medical Association

Early Use of Anticoagulants in Treatment of Myocardial Infarction

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Why the study?

Does early use of anticoagulants reduce death rate and thromboembolic complications in patients with myocardial infarction?

Population

Patients with myocardial infarction

Comparison

Early use of anticoagulants vs Other types of treatment

Design

Review

Authors

IWIrving S. WrightAmerican Heart Association

Discussion

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Implication

May support early anticoagulation in acute MI to reduce mortality and emboli; leaves open confirmation via modern RCTs balancing bleeding risks.

Structured PICO

Does early use of anticoagulants reduce death rate and thromboembolic complications in patients with myocardial infarction?

P
Population
Patients with myocardial infarction
I
Intervention
Early use of anticoagulants (ethyl biscoumacetate 1,200-1,500 mg and bishydroxycoumarin 200-300 mg orally, followed by daily bishydroxycoumarin 25-50 mg; optional heparin 75 mg subcutaneously)
C
Comparator
Other types of treatment
O
Outcome
Death ratehard clinical

Early use of anticoagulants in myocardial infarction reduces mortality and thromboembolic complications, though it requires careful laboratory monitoring and patient selection.

Cite This Study

Irving S. Wright (1957) studied this question.

synapsesocial.com/papers/6a1ce5cc0f544c23831dc91chttps://doi.org/10.1001/jama.1957.02970460008003

Topics

Anticoagulation in AF
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1"SELECTIVE" VERSUS "ROUTINE" USE OF ANTICOAGULANTS IN ACUTE MYOCARDIAL INFARCTION1954 · 28 citations
  2. 2ANTICOAGULANTS IN CORONARY THROMBOSIS WITH MYOCARDIAL INFARCTION1951 · 35 citations
  3. 3The Prevention of Thromboembolic Complications in Myocardial Infarction by Anticoagulant Therapy1956 · 16 citations
  4. 4THE SELECTIVE USE OF ANTICOAGULANTS IN ACUTE MYOCARDIAL INFARCTION BASED ON INITIAL PROGNOSIS1954 · 27 citations
  5. 5Myocardial Infarction: Its Clinical Manifestations and Treatment with Anticoagulants. A Study of 1031 Cases1955 · 37 citations