Emerging Concepts and Challenges in Rheumatoid Arthritis Gene Therapy

Figures

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  Figure 1. The dynamics of the publications/clinical trials number with keywords “monoclonal antibody” AND “rheumatoid arthritis” as of October 2019.

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  Figure 2. MicroRNA inhibits the translation of target mRNA (red cross on the black arrow). Circular RNAs (circRNA) may act as competitive inhibitor of microRNA preserving target protein expression.

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  Figure 3. Three types of gene-specific manipulations. Black boxes indicate genomic DNA. Yellow and violet ellipses indicate site-specific nucleases. Pink boxes indicate random insertions or deletions acquired during nonhomologous end joining. Dark grey box indicates a desired insert acquired during homology-directed repair. Light grey box indicates excised part of genomic DNA between two DNA double-strand breaks.

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  Figure 4. The dynamics of the number of publications with keywords “adeno-associated virus” AND “gene therapy” (red), “lentivirus” AND “gene therapy” (green), “retrovirus” AND “gene therapy” (blue), and “adenovirus” AND “gene therapy” (brown) as of May 2019.