Key result
Gene therapy for rheumatoid arthritis demonstrated feasibility and safety in a completed Phase I clinical trial of ex vivo gene transfer to the synovial lining of human joints.
Why the study?
Does gene therapy offer a feasible, safe, and effective treatment strategy for rheumatoid arthritis?
Population
Patients with rheumatoid arthritis and animal models of arthritis
Design
Review
Authors
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Continued efforts on novel biologics needed in refractory RA; leaves open optimal sequencing and long-term outcomes.
Does gene therapy offer a feasible, safe, and effective treatment strategy for rheumatoid arthritis?
Gene therapy shows promise as a potential long-term treatment strategy for rheumatoid arthritis, with early Phase I trials completed.
Ghivizzani et al. (2001) conducted a review in Rheumatoid arthritis. Gene therapy was evaluated. Gene therapy for rheumatoid arthritis demonstrated feasibility and safety in a completed Phase I clinical trial of ex vivo gene transfer to the synovial lining of human joints.
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