May 1, 1996Current Opinion in Rheumatology

Pathways to gene therapy in rheumatoid arthritis

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Population

Rheumatoid arthritis (general discussion and animal models)

Design

Review

Authors

CEChristopher H. EvansMayo Clinic PRPaul D. RobbinsUniversity of Minnesota

Discussion

Member takes

Implication

Supports first human gene therapy trial in arthritis; leaves open clinical efficacy and safety of ex vivo IL-1Ra transfer.

Structured PICO

Population

Rheumatoid arthritis (general discussion and animal models)

Intervention

Gene therapy (including various vectors such as retrovirus, adenovirus, herpes simplex virus, liposomes, and naked DNA, delivered locally or systemically, in vivo or ex vivo)

Gene therapy offers a novel approach for treating rheumatoid arthritis, with ex vivo techniques demonstrating sufficient promise in animal models to advance to human clinical trials.

Cite This Study

Evans et al. (1996) studied this question.

synapsesocial.com/papers/6a90551af009383eee841d87 https://doi.org/10.1097/00002281-199605000-00011

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Pathways to gene therapy in rheumatoid arthritis

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Pathways to gene therapy in rheumatoid arthritis

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider