May 1, 2000Current Opinion in Rheumatology
Gene transfer: from concept to therapy
Population
Rheumatoid arthritis (RA)
Design
Review
Authors
Discussion
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Member takes
Implication
Should not yet change arthritis practice; leaves open whether selective gene transfer improves outcomes in rheumatoid arthritis.
Structured PICO
P
Population
Rheumatoid arthritis (RA)
I
Intervention
Gene therapy/gene transfer (viral systems including retro- and adenoviruses, herpes virus-based systems, liposomes in combination with viral fusion proteins)
Gene therapy offers a promising approach for rheumatoid arthritis by targeting specific pathomechanisms such as inflammation and synovial cell apoptosis.
Cite This Study
Pap et al. (2000) studied this question.