What does this research mean for the field?

Accumulated creatine kinase MB (CK-MB) release is a valid and reliable measure for assessing the extent of left ventricular necrosis in acute anterior myocardial infarction, but it may overestimate infarct size in inferior myocardial infarction due to concomitant right ventricular necrosis. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

August 1, 1977Circulation

Correlation of angiographic estimates of myocardial infarct size and accumulated release of creatine kinase MB isoenzyme in man.

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Why the study?

Does accumulated CK-MB release correlate with angiographic estimates of myocardial infarct size in patients post-myocardial infarction?

Population

35 patients who underwent diagnostic angiography at a mean of 33 +/- 4 days post myocardial infarction (MI)

Comparison

Measurement of accumulated creatine kinase MB… vs Biplane left ventricular angiographic estimates…

Design

Cohort

Follow-up

mean 33 +/- 4 days post MI

Authors

WRWilliam J. RogersGeneral Cardiology HMHuey G. McDanielTulane University LSLloyd R. SmithIsland Health

Discussion

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Implication

Sigma CK-MB may aid noninvasive infarct sizing post-MI; extends enzymatic validation against angiographic %ACS and EF in no-prior-MI patients.

Structured PICO

Does accumulated CK-MB release correlate with angiographic estimates of myocardial infarct size in patients post-myocardial infarction?

Population

35 patients who underwent diagnostic angiography at a mean of 33 +/- 4 days post myocardial infarction (MI)

Intervention

Measurement of accumulated creatine kinase MB isoenzyme release (sigma CK-MB)

Comparator

Biplane left ventricular (LV) angiographic estimates of percent abnormally contracting segment (%ACS) and ejection fraction (EF)

Outcome

Correlation between sigma CK-MB and angiographic estimates of infarct size (%ACS and EF)surrogate

Limitations

Limitations may exist in certain cases of inferior MI, probably because of concomitant right and left ventricle necrosis

Cite This Study

Rogers et al. (1977) studied this question.

synapsesocial.com/papers/6a1cea35df63e2f8047565db https://doi.org/10.1161/01.cir.56.2.199

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Implication

Sigma CK-MB may aid noninvasive infarct sizing post-MI; extends enzymatic validation against angiographic %ACS and EF in no-prior-MI patients.

Correlation of angiographic estimates of myocardial infarct size and accumulated release of creatine kinase MB isoenzyme in man.

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Correlation of angiographic estimates of myocardial infarct size and accumulated release of creatine kinase MB isoenzyme in man.

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Also Consider