Why the study?
The study was conducted to investigate whether hypertension may be causally linked to left atrial and left ventricular structure and function.
Does genetic predisposition to hypertension causally alter left atrial and left ventricular structure and function?
Population
35,648 participants from the UK Biobank
Comparison
Hypertension genetic instruments vs non-exposure
Design
Two-sample Mendelian randomization study
Authors
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Supports hypertension's causal role in adverse LA/LV remodeling; leaves open whether BP lowering reverses these changes.
Does genetic predisposition to hypertension causally alter left atrial and left ventricular structure and function?
Mendelian randomization provides genetic evidence that hypertension causally leads to adverse left atrial and ventricular remodeling and dysfunction.
Sun et al. (2022) studied this question.
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