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March 1, 1985PEDIATRICS

Prevention of Bacterial Endocarditis

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Why the study?

Does prophylactic antibiotic administration prevent bacterial endocarditis in at-risk patients undergoing bacteremia-inducing procedures?

Population

Patients at risk of bacterial endocarditis undergoing procedures likely to cause bacteremia

Design

Guideline

Discussion

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Implication

Endorse targeted prophylaxis in high-risk patients; leaves open definitive efficacy pending controlled trials.

Structured PICO

Does prophylactic antibiotic administration prevent bacterial endocarditis in at-risk patients undergoing bacteremia-inducing procedures?

P
Population
Patients at risk of bacterial endocarditis (e.g., prosthetic heart valves, congenital anatomic defects, damaged or abnormal heart valves) undergoing procedures likely to cause bacteremia (e.g., dental, surgical)
I
Intervention
Prophylactic antibiotics initiated shortly before the procedure
O
Outcome
Prevention of bacterial endocarditis

This document provides recommendations for the use of prophylactic antibiotics to prevent bacterial endocarditis in at-risk patients undergoing procedures likely to cause bacteremia.

Limitations

  • No controlled clinical trials
  • Based on indirect information (in vitro studies, clinical experience, animal models)

Cite This Study

A 1985 study studied this question.

synapsesocial.com/papers/6a1cff6d28423f2ce504b559https://doi.org/10.1542/peds.75.3.603
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