Why the study?
Arterial hypertension is the leading cause of cardiovascular morbidity and mortality in older adults, but blood pressure control is challenging due to comorbidities, polypharmacy, and frailty.
Does anti-hypertensive therapy reduce cardiovascular mortality and morbidity in older adults?
Does anti-hypertensive therapy reduce cardiovascular mortality and morbidity in older adults?
While blood pressure reduction is beneficial and safe in ambulatory older adults, treatment must be highly individualized in those with frailty, polypharmacy, or cognitive impairment.
Supports cautious, individualized BP lowering in frail older adults; leaves open optimal regimens and targets for dedicated trials.
Vascular aging leads to arterial hypertension, which is the leading cause of cardiovascular mortality and morbidity in older adults. Blood pressure reduction is effective in reducing the cardiovascular risk and is safe in ambulatory older adults. It is important to note that blood pressure control in this group of patients is challenging because of comorbidities, polypharmacy, and frailty. Choice of pharmacotherapy is not simple and should be individualized.
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Bilen et al. (2020) studied this question.
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