April 1, 1996Physiological Reviews

Malignant hyperthermia: excitation-contraction coupling, Ca2+ release channel, and cell Ca2+ regulation defects

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Population

Malignant hyperthermia-susceptible (MHS) pigs and humans

Design

Review

Authors

JMJames R. MickelsonWashington State University CLCharles F. LouisMichigan State University

Discussion

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Implication

Human MH genetic heterogeneity limits direct translation from porcine RYR1 models; leaves open broader variant discovery for diagnostics and risk stratification.

Structured PICO

Population

Malignant hyperthermia-susceptible (MHS) pigs and humans

This review summarizes the molecular basis of malignant hyperthermia, highlighting the role of RYR1 mutations in pigs and the genetic heterogeneity in humans.

Cite This Study

Mickelson et al. (1996) studied this question.

synapsesocial.com/papers/6a1d0cc9d676c7290baf2d4e https://doi.org/10.1152/physrev.1996.76.2.537

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Implication

Human MH genetic heterogeneity limits direct translation from porcine RYR1 models; leaves open broader variant discovery for diagnostics and risk stratification.

Malignant hyperthermia: excitation-contraction coupling, Ca2+ release channel, and cell Ca2+ regulation defects

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Malignant hyperthermia: excitation-contraction coupling, Ca2+ release channel, and cell Ca2+ regulation defects

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider