Pharmaceuticals in the Soil and Plant Environment: a Review

Abstract Pharmaceuticals are a class of biologically active compounds used in human and veterinary medicine, while some of them may be applied for feed production and plant growth stimulation. To systemise the knowledge on pharmaceuticals in plant and soil environment, a literature review was performed. Active substances of pharmaceuticals and their metabolites are typically released into the environment through agricultural application of wastewater and sewage biosolids containing pharmaceuticals, derived from wastewater discharged by households, hospitals and other medical facilities. Another, no less important, source of pharmaceutical release are natural fertilisers (manure and slurry). The fate and behaviour of pharmaceuticals in the soil, including their mobility and availability to plants, depends on the soil physical, chemical and biological properties as well as on the properties of the substance itself. Pharmaceuticals introduced into the soil are taken up and retained in various plant parts. In general, the highest accumulation coefficients have been found in vegetative plant parts, in the following decreasing order: roots> leaves> stems, while the lowest in generative parts, such as grains of cereals.