What question did this study set out to answer?

To establish a quantitative framework for measuring internal iron transport, clearance rates, and utilization in human erythropoiesis.

January 1, 1970Medicine

Ferrokinetics in Man

View Full Paper

Ask AI

Bookmark

To establish a quantitative framework for measuring internal iron transport, clearance rates, and utilization in human erythropoiesis.
Monitored tracer clearance and erythrocyte incorporation following intravenous administration of radioactive iron.
Calculated compartment transfer rates among plasma transferrin, marrow erythroid precursors, and reticuloendothelial storage pools.
Plasma iron turnover rates reliably reflect total marrow erythroid cellularity and production activity.
Fractional incorporation of iron into circulating erythrocytes distinguishes effective erythropoiesis from premature intramedullary destruction.

Implication

Physiological investigation demonstrates quantitative pathways of iron turnover in humans, highlighting mechanisms governing erythropoiesis.

Abstract

FINCH, C. A.; DEUBELBEISS, K.; COOK, J. D.; ESCHBACH, J. W.; BARKER, L. A.; FUNK, D. D.; MARSAGLIA, G.; HILLMAN, R. S.; SLICHTER, S.; ADAMSON, J. W.; GANZONI, A.; GIBLETT, E. R. Author Information

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Finch et al. (1970) studied this question.

synapsesocial.com/papers/6a1d18ee28423f2ce504c63c https://doi.org/10.1097/00005792-197001000-00002

View Full Paper

Ask AI

Bookmark

Implication

Physiological investigation demonstrates quantitative pathways of iron turnover in humans, highlighting mechanisms governing erythropoiesis.

Abstract

FINCH, C. A.; DEUBELBEISS, K.; COOK, J. D.; ESCHBACH, J. W.; BARKER, L. A.; FUNK, D. D.; MARSAGLIA, G.; HILLMAN, R. S.; SLICHTER, S.; ADAMSON, J. W.; GANZONI, A.; GIBLETT, E. R. Author Information

Ferrokinetics in Man

Key Points

Implication

Abstract

Discussion

Cite This Study

Ferrokinetics in Man

Key Points

Implication

Abstract

Discussion

Cite This Study

Keep reading

Keep reading