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Harsh extreme-Earth and extra-Earth mortality sources pressure countervailing shifts in human life-history traits and survival-reproductive strategies, trading shorter lifespans and reproduction spans to hedge scarce gametes with sex-chromosome resilience. Darwinian trajectories for genotypes and phenotypes nonetheless remain unknown for future Earth-population sustainability and deep-space colonization. Controversial technology-assisted human evolution may be needed to narrow anthropological evolutionary-medicine disparities and prevent Humanity's extinction.
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