Mechanistic review reveals that excessive reactive oxygen species from NADPH oxidases drive cell death in the central nervous system, highlighting therapeutic potential for neurodegeneration.
Significance: The nicotinamide adenine dinucleotide phosphate oxidase (NOX) enzyme family, located in the central nervous system, is recognized as a source of reactive oxygen species (ROS) in the brain. Despite its importance in cellular processes, excessive ROS generation leads to cell death and is involved in the pathogenesis of neurodegenerative disorders.
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Fiadeiro et al. (2024) studied this question.
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