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Summarize multiscale design strategies that overcome spatial confinement and microenvironmental stress to optimize the catalytic performance of enzymes encapsulated within reticular frameworks.

December 12, 2025Advanced ScienceOpen Access

Reticular Chemistry: A Versatile Platform for Engineering Heterogenous Biocatalysts

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Summarize multiscale design strategies that overcome spatial confinement and microenvironmental stress to optimize the catalytic performance of enzymes encapsulated within reticular frameworks.
Reviewed enzyme encapsulation mechanisms across metal-organic frameworks (MOFs), covalent organic frameworks (COFs), and hydrogen-bonded organic frameworks (HOFs).
Categorized engineering solutions across three tiers: nano- and macro-scale material tuning, molecular interface design, and protein surface engineering.
Identified spatial confinement, non-native interactions, and altered microenvironments within framework pores as the primary drivers of impaired enzyme dynamics.
Demonstrated that multiscale tuning of pore geometry, interface chemistry, and protein surface residues restores biocatalytic activity across distinct framework types.
Highlighted that nano-bio interfacial interactions enable framework-enzyme hybrids to execute customized, non-native catalytic functions.

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Implication

Review outlines multiscale strategies to preserve enzyme activity in reticular frameworks, highlighting design principles for robust heterogeneous biocatalysts.

Cite This Study

Liu et al. (2025) studied this question.

synapsesocial.com/papers/6a1d195efeb402ac612f29e5 https://doi.org/10.1002/advs.202519207

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Implication

Review outlines multiscale strategies to preserve enzyme activity in reticular frameworks, highlighting design principles for robust heterogeneous biocatalysts.

Reticular Chemistry: A Versatile Platform for Engineering Heterogenous Biocatalysts

Key Points

Discussion

Implication

Cite This Study

Reticular Chemistry: A Versatile Platform for Engineering Heterogenous Biocatalysts

Key Points

Discussion

Implication

Cite This Study

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