What question did this study set out to answer?

To assess the relationship between endometriosis and IVF treatment outcomes across different stages of disease severity.

July 3, 2013BJOG An International Journal of Obstetrics & Gynaecology

The effect of endometriosis on in vitro fertilisation outcome: a systematic review and meta‐analysis

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Authors

HHHM HarbUniversity of Birmingham IGIoannis GallosWorld Health Organization JCJustin ChuUniversity of Louisville

Discussion

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Implication

Systematic review and meta-analysis reveals reduced implantation and pregnancy rates in women with severe endometriosis undergoing IVF, indicating disease stage impairs reproductive success.

Key Points

To assess the relationship between endometriosis and IVF treatment outcomes across different stages of disease severity.
Searched MEDLINE, EMBASE, Cochrane Library, and Web of Science from inception to December 2012 without language restrictions.
Identified 27 observational studies including 8,984 women undergoing IVF, categorizing participants by endometriosis stage and assessing study quality using the Newcastle-Ottawa Scale.
Extracted relative risk (RR) estimates for fertilisation, implantation, clinical pregnancy, and live birth rates to conduct meta-analyses.
Stage I/II endometriosis was associated with a significant decrease in fertilisation rates compared with non-endometriosis controls (RR = 0.93, 95% CI 0.87–0.99, P = 0.03).
Stage III/IV endometriosis was associated with a significant reduction in implantation rates (RR = 0.79, 95% CI 0.67–0.93, P = 0.006) and clinical pregnancy rates (RR = 0.79, 95% CI 0.69–0.91, P = 0.0008).

Cite This Study

Harb et al. (2013) studied this question.

synapsesocial.com/papers/6a1d1c4e73c56dd1bd2f31ee https://doi.org/10.1111/1471-0528.12366

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Implication

Systematic review and meta-analysis reveals reduced implantation and pregnancy rates in women with severe endometriosis undergoing IVF, indicating disease stage impairs reproductive success.

The effect of endometriosis on in vitro fertilisation outcome: a systematic review and meta‐analysis

Discussion

Member takes

Implication

Key Points

Cite This Study

The effect of endometriosis on in vitro fertilisation outcome: a systematic review and meta‐analysis

Discussion

Member takes

Implication

Key Points

Cite This Study

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