Why the study?
Growing evidence supports the importance of lifestyle and environmental exposures for immune health, prompting a summary of how exposome components affect immune function and inflammation during the COVID-19 pandemic.
Do exposome improvements enhance immune health and help prevent or ameliorate COVID-19?
Do exposome improvements enhance immune health and help prevent or ameliorate COVID-19?
Promoting a healthy exposome, including lifestyle and environmental factors, is crucial for maintaining immune health and may help prevent or ameliorate COVID-19 and improve vaccine response.
May support exposome strategies for immune resilience in pandemics; hypothesis-generating and requires prospective trials before practice change.
Growing evidence supports the importance of lifestyle and environmental exposures-collectively referred to as the 'exposome'-for ensuring immune health. In this narrative review, we summarize and discuss the effects of the different exposome components (physical activity, body weight management, diet, sun exposure, stress, sleep and circadian rhythms, pollution, smoking, and gut microbiome) on immune function and inflammation, particularly in the context of the current coronavirus disease 2019 (COVID-19) pandemic. We highlight the potential role of 'exposome improvements' in the prevention-or amelioration, once established-of this disease as well as their effect on the response to vaccination. In light of the existing evidence, the promotion of a healthy exposome should be a cornerstone in the prevention and management of the COVID-19 pandemic and other eventual pandemics.
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Morales et al. (2021) studied this question.
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