Why the study?
Does overexpression of ATRAP reduce Ang II-mediated hypertrophic responses in cardiomyocytes?
Does overexpression of ATRAP reduce Ang II-mediated hypertrophic responses in cardiomyocytes?
ATRAP promotes downregulation of the AT1R and attenuates Ang II-mediated hypertrophic responses in cardiomyocytes, highlighting a potential molecular mechanism to target cardiac hypertrophy.
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ATRAP overexpression may mitigate Ang II-driven cardiomyocyte hypertrophy; leaves open translation to in vivo remodeling or clinical disease.
Tanaka et al. (2005) studied this question.
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