Why the study?
The relationship between age and coronary endothelial function in people with human immunodeficiency virus had not previously been examined.
Does age correlate with coronary endothelial function differently in people with HIV compared to HIV-negative individuals?
Does age correlate with coronary endothelial function differently in people with HIV compared to HIV-negative individuals?
Coronary endothelial function is impaired in people with HIV regardless of age, lacking the typical age-related decline seen in HIV-negative individuals, suggesting HIV-specific factors drive early and persistent vascular dysfunction.
Suggests HIV-specific endothelial impairment independent of age; hypothesis-generating for targeted vascular risk assessment in PWH.
This is the first study to examine the relationship between age and coronary endothelial function (CEF) in people with human immunodeficiency virus (HIV) (PWH). CEF was assessed using magnetic resonance imaging (MRI) in people with and without HIV. Although age and CEF were significantly inversely related in individuals without HIV, there was no association between age and CEF in PWH.
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Ziogos et al. (2023) studied this question.
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