Demonstrates enhanced fracture healing in KDM6A-knockout mice, indicating a role for oxygen sensing in bone regeneration.
, KDM6A‑knockout mice exhibited osteogenic defects and delayed fracture healing compared with control mice. KDM6A serves as a pivotal oxygen sensor that drives CH‑to‑osteoblast transdifferentiation and enhances fracture healing through Wnt/β‑catenin pathway activation. The KDM6A‑mediated oxygen response mechanism is a potential target for enhancing bone regeneration during fracture repair.
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Rong et al. (2026) studied this question.
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