What question did this study set out to answer?

This study aims to investigate the role of KDM6A in chondrocyte-to-osteoblast transdifferentiation and fracture healing through Wnt/beta-catenin pathway activation.

June 1, 2026International Journal of Molecular Medicine0 citationsOpen Access

Oxygen‑sensing histone demethylase KDM6A modulates chondrocyte‑to‑osteoblast transdifferentiation by activating the Wnt/β‑catenin pathway

YRYi RongNanjing University of Chinese Medicine HYHao YuNanjing University of Chinese Medicine HYHeng YinNanjing University of Chinese Medicine

Key Points

This study aims to investigate the role of KDM6A in chondrocyte-to-osteoblast transdifferentiation and fracture healing through Wnt/beta-catenin pathway activation.
Used KDM6A-knockout mice to evaluate osteogenic defects and fracture healing.
Compared outcomes with control mice to assess differences in bone regeneration and transdifferentiation activity.
KDM6A-knockout mice showed significant osteogenic defects and delayed fracture healing compared to controls.
Activation of the Wnt/beta-catenin pathway was shown to be critical for KDM6A's role in these processes.

Abstract

, KDM6A‑knockout mice exhibited osteogenic defects and delayed fracture healing compared with control mice. KDM6A serves as a pivotal oxygen sensor that drives CH‑to‑osteoblast transdifferentiation and enhances fracture healing through Wnt/β‑catenin pathway activation. The KDM6A‑mediated oxygen response mechanism is a potential target for enhancing bone regeneration during fracture repair.

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