The broad spectrum of myeloid cell migration strategies

Myeloid immune cells play crucial roles in tissue homeostasis, wounding, inflammation, infection, and allergic reactions. Individual myeloid cell types have evolved unique dynamics adapted to their specific functions in the tissues, ranging from long-term residency to rapid migration. The interplay between actin network expansion and contraction underlies the movement of all myeloid cells, but distinct cell types utilize receptor-mediated adhesion differently when interacting with their environment. This results in cell-type specific morphologies and motility behaviors, from fast amoeboid locomotion to slow mesenchymal-like motility. We provide an overview of the migration modes employed by neutrophils, monocytes, macrophages, dendritic cells, and mast cells, highlighting the wide spectrum of migration strategies within the myeloid compartment.