Integrative analysis reveals intra-tumoral microbial enterotypes shape host transcriptomes in colorectal cancer

Key Points

• This research aims to understand how intra-tumoral microbiota affect host transcriptomes and immune response in colorectal cancer.
• Conducted integrative analysis of microbial enterotypes and host transcriptomes in colorectal cancer samples.
• Assessed the relationship between microbiota and immune modulation.
• Explored implications for microbiome-based molecular stratification.
• Identified that intra-tumoral microbiota significantly shape host transcriptomes in colorectal cancer.
• Demonstrated a link between microbiota and T cell exhaustion/immune evasion.
• Suggested that targeting these microbiota could lead to new therapeutic strategies.