High intratumoral CD8 positive T cell infiltration associated with pathologic complete response after neoadjuvant immunotherapy in locally advanced colon cancer
Randomized trial shows association between CD8 T cell density and response in dMMR colon cancer, suggesting a promising biomarker.
Key Points
To investigate the relationship between CD8+ T cell infiltration and pathologic complete response in dMMR colon cancer after neoadjuvant immunotherapy.
Three cases of locally advanced dMMR colon cancer were treated with neoadjuvant immune checkpoint inhibitors (ICI).
Pre-treatment biopsy specimens were analyzed for CD8+ T-cell density using immunohistochemistry.
Patients underwent curative resection and achieved a pathologic complete response.
All patients achieved a pathologic complete response (pCR) after treatment.
Pre-treatment biopsy samples indicated CD8+ T-cell densities of 244.1, 370.4, and 433.5 cells/mm2.
Suggests a potential link between high CD8+ T cell infiltration and favorable response to immunotherapy.