Preoperative uric acid-to-albumin ratio independently predicted 3-year all-cause mortality after isolated coronary artery bypass grafting with an OR of 6.701.
Observational (n=184)
No
Do preoperative serum uric acid levels and uric acid-to-albumin ratio predict 3-year mortality in patients undergoing isolated CABG?
Preoperative serum uric acid and the uric acid-to-albumin ratio are significant independent predictors of 3-year mortality following isolated CABG.
Effect estimate: OR 6.701 (95% CI 1.406-31.946)
Absolute Event Rate: 12.9% vs 2%
p-value: p=0.017
Background: This study aimed to evaluate and compare the prognostic value of preoperative serum uric acid (UA) levels and the uric acid-to-albumin ratio (UAR) in predicting three-year mortality following isolated coronary artery bypass grafting (CABG).Methods: We screened a total of 480 patients retrospectively, and analysed 184 patients who underwent isolated CABG between January 2021 and January 2023. Preoperative laboratory data, including UA and albumin levels, were recorded, and UAR was calculated.Results: The primary endpoint was all-cause mortality during a three-year follow-up period. Reciever operating characteristic (ROC) curve analysis and multivariable logistic regression were employed to identify independent predictors of mortality. The mean age of the participants was 60.0 ± 9.2 years. ROC curve analysis demonstrated significant predictive ability for both UAR (AUC: 0.767, p = 0.001) and UA (AUC: 0.768, p = 0.001) regarding 3-year mortality. The optimal cut-off value for UAR was 1.6233 (84.6% sensitivity, 56.7% specificity). In multivariable logistic regression models, UAR (OR: 6.701, p = 0.017) and UA (OR: 1.745, p = 0.011) were both identified as independent predictors of mortality, along with age. Although the UA-based model provided slightly better overall calibration (Hosmer-Lemeshow p = 0.109 vs 0.094) and marginally higher explanatory power (Nagelkerke R2: 0.405 vs 0.396). Conclusion: Both preoperative UA and UAR were identified as independent predictors of long-term mortality after isolated CABG and demonstrated significant prognostic utility for three-year survival assessme.
Aksoy et al. (Fri,) conducted a observational in Isolated Coronary Artery Bypass Grafting (CABG) (n=184). High Preoperative Uric Acid-to-Albumin Ratio (UAR >1.6233) vs. Low Preoperative Uric Acid-to-Albumin Ratio (UAR <1.6233) was evaluated on 3-year all-cause mortality (OR 6.701, 95% CI 1.406-31.946, p=0.017). Preoperative uric acid-to-albumin ratio independently predicted 3-year all-cause mortality after isolated coronary artery bypass grafting with an OR of 6.701.