What does this research mean for the field?

In the normal aging adult and hypertrophic heart, beta-myosin heavy chain (beta-MHC) gene expression is a marker of local fibrosis rather than an obligatory consequence of cellular hypertrophy. Novelty: ClaimNovelty.CONTRADICTORY. Consensus alignment: ConsensusAlignment.CHALLENGES_CONSENSUS.

October 27, 2006Proceedings of the National Academy of SciencesOpen Access

Fibrosis, not cell size, delineates β-myosin heavy chain reexpression during cardiac hypertrophy and normal aging in vivo

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Implication

Single-cell beta-MHC mapping in murine hypertrophy extends mechanistic detail; leaves open human translation and therapeutic targeting.

Cite This Study

Pandya et al. (2006) studied this question.

synapsesocial.com/papers/6a1d225aba65f5ee325ddd18 https://doi.org/10.1073/pnas.0607700103

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Fibrosis, not cell size, delineates β-myosin heavy chain reexpression during cardiac hypertrophy and normal aging in vivo

Key Points

Discussion

Implication

Cite This Study

Fibrosis, not cell size, delineates β-myosin heavy chain reexpression during cardiac hypertrophy and normal aging in vivo

Key Points

Discussion

Implication

Cite This Study

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