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Response to the letter « Clarifying renal-risk inference from hsCRP in CKD » | Synapse

June 1, 2026Open Access

Response to the letter « Clarifying renal-risk inference from hsCRP in CKD »

Key Points

To clarify the competing risks of death in relation to kidney failure when using hsCRP measurements.
Utilized the TriNetX online statistical platform for analysis
Performed a dichotomization of hsCRP from a single baseline value
Noted limitations prevented Fine-Gray analysis
Acknowledged that death is a significant competing event for kidney failure
Emphasized the exploratory nature of the findings
Discussed the debatable method of hsCRP analysis

Abstract

We agree with Wang et al1 that death was a competing event for kidney failure. Unfortunately, the limited tools on the TriNetX online statistical platform did not allow us to perform a Fine-Gray analysis. HsCRP was dichotomized from a single baseline value2, and this choice is debatable. Our results are exploratory by nature.

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Cite This Study

Halimi et al. (Fri,) studied this question.

synapsesocial.com/papers/6a1d228d02fbce91306384bf https://doi.org/https://doi.org/10.1016/j.ekir.2026.106634