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June 1, 2026BMC PediatricsOpen Access

Impact of optimized antiretroviral therapy on virological and nutritional outcomes among HIV infected adolescents in Cameroon

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Multicenter study evaluates viral suppression and nutritional improvement in HIV-infected adolescents using optimized therapy.

Evaluating the impact of optimized antiretroviral therapy on virological and nutritional outcomes among HIV-infected adolescents.
Multicenter cross-sectional study conducted from February to June 2022 in Douala, Cameroon.
Included 599 adolescents aged 10–19 years receiving ART for at least six months. Collecting sociodemographic and clinical data related to optimized therapy.
Statistical analysis using SPSS version 25 with a significance threshold set at p < 0.05.
Before optimized therapy, 84.2% had viral suppression, increasing to 94.6% after switching to optimized therapy.
Adolescents on optimized therapy had 3.3 times higher odds of achieving viral load suppression (OR: 3.3; 95% CI: 2.0–5.6; p < 0.001).
Optimized regimens significantly reduced moderate malnutrition (OR: 0.38; 95% CI: 0.16–0.91; p = 0.042) and improved weight and BMI.

Penda et al. (2026) studied this question.

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