Why the study?
How do fatiguing IHG and PECO affect baroreflex resetting of MSNA and sympathetic APs in humans?
How do fatiguing IHG and PECO affect baroreflex resetting of MSNA and sympathetic APs in humans?
Descending central versus ascending muscle metaboreflex mechanisms differentially affect baroreflex resetting of sympathetic action potentials during exercise.
Does not support changes in clinical autonomic assessment; leaves open differential metaboreflex effects on sympathetic baroreflex gain.
This study provides new insight to baroreflex resetting of MSNA during exercise in humans. Both fatiguing IHG and PECO reset baroreflex control of sympathetic APs to higher blood pressures and greater MSNA. However, only PECO increased baroreflex threshold gain of medium-sized sympathetic APs, an effect that was concealed when focusing on the integrated MSNA neurogram to quantify baroreflex gain. These data suggest that descending central versus ascending muscle metaboreflex mechanisms differentially affect baroreflex resetting of sympathetic APs.
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Klassen et al. (2023) studied this question.
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