What does this research mean for the field?

During orthostasis, the cardiovagal and ventilatory baroreflexes reset without changing gain, while the sympathetic baroreflex is both shifted and augmented to increase peripheral resistance and defend against hypotension. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

January 1, 2012Frontiers in PhysiologyOpen Access

The Arterial Baroreflex Resets with Orthostasis

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Why the study?

Does orthostasis cause resetting of the arterial baroreflexes compared to the supine position?

Population

Human subjects (specific demographics and sample size not stated)

Comparison

Upright tilt with blood pressure manipulation… vs Supine position

Design

Other

Authors

CSChristopher E. SchwartzLouisiana State University Health Sciences Center New Orleans JSJulian M. StewartNew York Medical College

Discussion

Member takes

Implication

Baroreflex resetting during orthostasis may bolster hypotension defense; leaves open relevance in autonomic or cardiovascular disease.

Structured PICO

Does orthostasis cause resetting of the arterial baroreflexes compared to the supine position?

Population

Human subjects (specific demographics and sample size not stated)

Intervention

Upright tilt (orthostasis) with blood pressure manipulation using the modified Oxford method (bolus injections of sodium nitroprusside followed by phenylephrine)

Comparator

Supine position

Outcome

Arterial baroreflex responses (relationships between systolic BP and HR, mean BP and ventilation, and diastolic BP and sympathetic nerve activity)surrogate

Orthostasis resets the cardiovagal and ventilatory baroreflexes and augments the sympathetic baroreflex, improving the physiological defense against hypotension.

Cite This Study

Schwartz et al. (2012) studied this question.

synapsesocial.com/papers/6a1d23271c2cbcb15c5dd375 https://doi.org/10.3389/fphys.2012.00461

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The Arterial Baroreflex Resets with Orthostasis

Discussion

Member takes

Implication

Structured PICO

Cite This Study

The Arterial Baroreflex Resets with Orthostasis

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider