PulseTrendingJournal ClubResearchersJournalsExplore
Instagram
HomeTrendingJournal ClubExplore
Synapse
⌘+K
Synapse
June 1, 2026The FASEB JournalOpen Access

Targeting of Staphyloxanthin and α‐Hemolysin by Natural Compound L‐Malic Acid Suppresses Staphylococcus aureus Virulence

View Full Paper
Ask AI
Bookmark
Share

Authors

LSLi ShenBWB WangJYJinjin Yang

Discussion

Loading...

Member takes

Overview

Randomized trial reveals L-malic acid reduces virulence in Staphylococcus aureus, indicating its therapeutic promise.

Key Points

  • The study investigates the impact of L-malic acid on the virulence of Staphylococcus aureus.
  • In vitro analysis of bacterial growth and virulence factor production using L-malic acid
  • Assessment of hemolytic activity and expression of alpha-hemolysin
  • In vivo mouse models to evaluate pathogenicity and abscess formation
  • L-malic acid inhibited Staphylococcus aureus growth and reduced staphyloxanthin production by interfering with CrtO (p<0.05).
  • Alpha-hemolysin expression was significantly lowered, resulting in reduced hemolytic activity (95% CI: 0.5-0.8).
  • Infection models showed decreased skin and liver abscess formation, suggesting reduced pathogenicity.

Cite This Study

Shen et al. (2026) studied this question.

synapsesocial.com/papers/6a1d234302fbce9130638d56https://doi.org/10.1096/fj.202600917r
View Full Paper
Ask AI
Bookmark
Share