What question did this study set out to answer?

This study aims to elucidate the distribution of Burkholderia pseudomallei seroreactivity and its environmental correlates among febrile patients in northern Vietnam.

June 1, 2026GeoHealthOpen Access

Hospital‐Based Cross‐Sectional Study of Burkholderia pseudomallei Seroreactivity Among Febrile Patients in Northernmost Vietnam: Near‐Neighbor Bloodstream Isolates, Environmental Correlates, and Spatial Clustering

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Authors

MMMorgan C. MetrailerUniversity of Florida TQTran Thi Le QuyenVietnam National University, Hanoi KPKhang PhamNational Institute Of Hygiene And Epidemiology

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Implication

Cross-sectional study identifies Burkholderia pseudomallei seroreactivity and environmental factors in febrile patients, suggesting need for surveillance.

Key Points

This study aims to elucidate the distribution of Burkholderia pseudomallei seroreactivity and its environmental correlates among febrile patients in northern Vietnam.
Conducted a cross-sectional study in six northernmost provinces of Vietnam with 2,440 febrile patients (2020–2023).
Used Burkholderia pseudomallei-specific IgG ELISAs to measure serological responses.
Performed spatial analysis and whole genome sequencing on a subset of patients.
Seropositivity in febrile patients was higher during the wet season, with significant correlation to rainfall and proximity to waterways.
Spatial analysis revealed seropositivity hotspots, indicating heterogeneous distributions.
WGS identified near-neighbor species of B. pseudomallei, which complicate diagnosis.

Cite This Study

Metrailer et al. (2026) studied this question.

synapsesocial.com/papers/6a1d234302fbce9130638d6a https://doi.org/10.1029/2025gh001606

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Implication

Cross-sectional study identifies Burkholderia pseudomallei seroreactivity and environmental factors in febrile patients, suggesting need for surveillance.

Hospital‐Based Cross‐Sectional Study of Burkholderia pseudomallei Seroreactivity Among Febrile Patients in Northernmost Vietnam: Near‐Neighbor Bloodstream Isolates, Environmental Correlates, and Spatial Clustering

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Implication

Key Points

Cite This Study

Hospital‐Based Cross‐Sectional Study of Burkholderia pseudomallei Seroreactivity Among Febrile Patients in Northernmost Vietnam: Near‐Neighbor Bloodstream Isolates, Environmental Correlates, and Spatial Clustering

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Key Points

Cite This Study

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