Why the study?
Does gadobenate dimeglumine increase the rate of allergic-like reactions compared to gadopentetate dimeglumine?
Population
105,607 injections of gadolinium-based contrast media
Comparison
Gadobenate dimeglumine vs Gadopentetate dimeglumine
Design
Cohort
Follow-up
5.5 years (2 years before and 3.5 years after substitution)
Authors
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May reflect Weber effect after agent switch rather than true difference; leaves open gadolinium contrast safety comparisons.
Does gadobenate dimeglumine increase the rate of allergic-like reactions compared to gadopentetate dimeglumine?
A transient increase in reported allergic-like reactions after switching to gadobenate dimeglumine suggests a Weber effect rather than a true difference in safety profile.
Davenport et al. (2012) studied this question.
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