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June 10, 2005StrokeOpen Access

The recanalization rate was significantly higher in women compared to men (94% versus 59%; P=0.02).

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Why the study?

Does arterial recanalization rate differ between women and men after IV tPA for acute ischemic stroke?

Population

39 patients with acute ischemic stroke who received IV tPA within 6 hours of onset and had follow-up…

Comparison

Intravenous tissue plasminogen activator within… vs Men versus women

Design

Cohort

Follow-up

within 72 hours

Authors

SSSean I. SavitzGSGottfried SchlaugLCLouis R. Caplan

Discussion

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Member takes

Overview

Should not yet alter tPA protocols by sex; hypothesis-generating for differential recanalization and requires prospective validation.

Structured PICO

Does arterial recanalization rate differ between women and men after IV tPA for acute ischemic stroke?

P
Population
39 patients (22 men, 17 women) with acute ischemic stroke (large artery anterior circulation strokes) who received IV tPA within 6 hours of onset and had follow-up vascular study within 72 hours
I
Intervention
Intravenous tissue plasminogen activator (IV tPA) within 6 hours of stroke onset
C
Comparator
Men versus women
O
Outcome
Arterial recanalization ratesurrogate

Women with acute ischemic stroke are significantly more likely to achieve arterial recanalization than men following intravenous tPA administration.

Limitations

  • Small sample size
  • Preliminary findings requiring validation in larger prospective studies

Cite This Study

Savitz et al. (2005) studied this question.

synapsesocial.com/papers/6a1d24edba65f5ee325de2b3https://doi.org/10.1161/01.str.0000170647.42126.a8
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