Srsf7 Stabilization by PIWI-interacting RNA AB352916 Orchestrates Cardiac Fibrosis via Enhancing Pkm Alternative Splicing

Key Points

• This research aims to explore how the stabilization of Srsf7 by PIWI-interacting RNA AB352916 affects cardiac fibrosis.
• Investigated the impact of PIWI-interacting RNA AB352916 on Srsf7 stabilization.
• Examined the resulting changes in Pkm alternative splicing.
• Analyzed the effects on cardiac fibrosis in relevant cellular models.
• Srsf7 stabilization was significantly enhanced by PIWI-interacting RNA AB352916.
• Increased Pkm alternative splicing led to heightened markers of cardiac fibrosis.
• Presence of PIWI-interacting RNA correlated with elevated levels of cardiac fibrosis indicators.