What does this research mean for the field?

An extrahepatic receptor-associated protein (RAP)-sensitive mechanism, independent of the low-density lipoprotein receptor (LDLR) and LDLR-related protein (LRP), regulates the metabolism of triglyceride-rich lipoproteins by affecting the functional maturation of lipoprotein lipase. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

December 1, 1999Journal of Biological ChemistryOpen Access

An Extrahepatic Receptor-associated Protein-sensitive Mechanism Is Involved in the Metabolism of Triglyceride-rich Lipoproteins

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Population

Mice that lack both LRP and LDLR (MX1cre(+)LRP(flox/flox)LDLR(-/-)) in their livers

Design

Preclinical

Authors

BVBart J.M. van VlijmenLeiden University Medical Center ARAstrid RohlmannHoward Hughes Medical Institute SPShallee T. PageUniversity of Vermont

Discussion

Member takes

Implication

Should not yet change clinical triglyceride management; hypothesis-generating for RAP's role in LPL maturation independent of LDLR/LRP.

Structured PICO

Population

Mice that lack both LRP and LDLR (MX1cre(+)LRP(flox/flox)LDLR(-/-)) in their livers

Intervention

Adenovirus-mediated gene transfer to overexpress receptor-associated protein (RAP)

Outcome

Metabolism of chylomicron and very low density lipoprotein (VLDL) remnants in vivo (plasma lipid distribution and lipoprotein lipase levels)surrogate

An extrahepatic RAP-sensitive process independent of LDLR or LRP is involved in the metabolism of triglyceride-rich lipoproteins, likely by affecting the functional maturation of lipoprotein lipase.

Cite This Study

Vlijmen et al. (1999) studied this question.

synapsesocial.com/papers/6a1d2690ba65f5ee325de5ee https://doi.org/10.1074/jbc.274.49.35219

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An Extrahepatic Receptor-associated Protein-sensitive Mechanism Is Involved in the Metabolism of Triglyceride-rich Lipoproteins

Discussion

Member takes

Implication

Structured PICO

Cite This Study

An Extrahepatic Receptor-associated Protein-sensitive Mechanism Is Involved in the Metabolism of Triglyceride-rich Lipoproteins

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider