Why the study?
Does inhibition of the lncRNA Meg3 prevent cardiac fibrosis and diastolic dysfunction in murine models of pressure overload?
Does inhibition of the lncRNA Meg3 prevent cardiac fibrosis and diastolic dysfunction in murine models of pressure overload?
Inhibition of the lncRNA Meg3 prevents cardiac fibrosis and improves diastolic function in murine models of pressure overload by regulating MMP-2 production.
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Meg3 inhibition merits exploration as antifibrotic target in pressure-overload models; leaves open translation to human HFpEF therapy.
Piccoli et al. (2017) studied this question.
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