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February 2, 1963JAMA

Treatment of Early Cancer of the Prostate

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Authors

HJHugh J. JewettJohns Hopkins University

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Implication

Randomized trial compares surgical outcomes with endocrine treatment in prostatic cancer, suggesting surgery may be more effective.

Key Points

  • This study aims to compare the long-term outcomes of radical perineal prostatectomy versus endocrine treatment in localized prostatic cancer.
  • Compared outcomes of 444 patients who underwent radical perineal prostatectomy at Johns Hopkins Hospital.
  • Evaluated results after 15 years of treatment.
  • Assessed comparable cases receiving endocrine therapy.
  • Radical perineal prostatectomy showed a significant reduction in mortality rates compared to endocrine treatment.
  • Surgery resulted in fewer long-term complications than those observed with endocrine manipulation.

Cite This Study

Hugh J. Jewett (1963) studied this question.

synapsesocial.com/papers/6a1d2804ba3016ff712f2c33https://doi.org/10.1001/jama.1963.63700050037023b
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Results of Radical Perineal Prostatectomy1969 · 54 citations
  2. 2RADICAL PERINEAL PROSTATECTOMY FOR CARCINOMA1954 · 54 citations
  3. 3Radical Perineal Prostatectomy: Its Past, Present and Possible Future1967 · 100 citations
  4. 4Radical Prostatectomy versus Watchful Waiting in Early Prostate Cancer2011 · 1,904 citations
  5. 5Changing nationwide trends away from overtreatment among patients undergoing radical prostatectomy over the past 25 years2023 · 6 citations