Why the study?
Renal ischemia-reperfusion injury causes high morbidity and mortality without effective therapies, and although sex hormones play an evident role in sexual dimorphism of renal injury, the exact underlying mechanisms remain to be elucidated.
What are the molecular mechanisms and therapeutic implications of sexual dimorphism in renal ischemia-reperfusion injury?
Design
Review
Authors
Loading...
Sex differences in renal IRI susceptibility warrant inclusion in risk models; leaves open hormone-targeted trials for confirmation.
What are the molecular mechanisms and therapeutic implications of sexual dimorphism in renal ischemia-reperfusion injury?
This review highlights the importance of sexual dimorphism and sex hormones in the pathophysiology of renal ischemia-reperfusion injury, suggesting potential novel therapeutic strategies.
Hosszú et al. (2020) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: