What does this research mean for the field?

Endothelium-derived relaxing factor/nitric oxide (EDNO) significantly modulates the vasoconstrictor action of Angiotensin II in afferent arterioles but not efferent arterioles, contributing to the higher sensitivity of efferent arterioles to Angiotensin II. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

May 1, 1993Journal of Clinical InvestigationOpen Access

Endothelium-derived relaxing factor/nitric oxide modulates angiotensin II action in the isolated microperfused rabbit afferent but not efferent arteriole.

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Population

Isolated microperfused rabbit afferent (Af) and efferent (Ef) arterioles

Comparison

Angiotensin II perfusion at varying… vs Nontreated arterioles and comparison between…

Design

Preclinical

Authors

SISadayoshi ItoVascular Medicine SAShuji ArimaKindai University Sakai Hospital YRY L RenRenmin University of China

Discussion

Member takes

Implication

NO differentially attenuates Ang II constriction in afferent but not efferent arterioles in rodents; leaves open relevance to human glomerular hemodynamics.

Structured PICO

Population

Isolated microperfused rabbit afferent (Af) and efferent (Ef) arterioles

Intervention

Angiotensin II (Ang II) perfusion at varying concentrations (10(-11) to 10(-8) M) with or without 10(-4) M nitro-L-arginine methyl ester (L-NAME) pretreatment

Comparator

Nontreated arterioles and comparison between afferent and efferent arterioles

Outcome

Change in arteriolar luminal diametersurrogate

Endothelium-derived nitric oxide significantly modulates the vasoconstrictor action of Angiotensin II in afferent but not efferent arterioles, contributing to their differential sensitivity.

Cite This Study

Ito et al. (1993) studied this question.

synapsesocial.com/papers/6a1d280fb1a9bd2ac02f1671 https://doi.org/10.1172/jci116423

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Implication

NO differentially attenuates Ang II constriction in afferent but not efferent arterioles in rodents; leaves open relevance to human glomerular hemodynamics.

Endothelium-derived relaxing factor/nitric oxide modulates angiotensin II action in the isolated microperfused rabbit afferent but not efferent arteriole.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Endothelium-derived relaxing factor/nitric oxide modulates angiotensin II action in the isolated microperfused rabbit afferent but not efferent arteriole.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider