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Link (1) suggested in 1948 that the coumarin compound warfarin be used as a rodenticide. Its first human use was in a suicide attempt in 1952 (2). Although warfarin has been employed in- creasingly in the treatment of thromboembolic disorders (3-5), no published reports of its physi- ologic disposition in man have appeared, probably owing largely to the lack of a suitable method for its measurement in biologic fluids (6).
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O’Reilly et al. (1963) studied this question.
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