Alternative Strategies for the Fmoc Solid‐Phase Synthesis of O4‐Phospho‐L‐tyrosine‐Containing Peptides

Abstract A number of biologically relevant O 4 ‐phospho‐L‐tyrosine‐containing peptides have been synthesized by either the global phosphorylation of the side‐chain‐unprotected L‐tyrosine moiety in presynthesized resin‐bound peptides or alternatively by the incorporation of suitably protected O 4 ‐phospho‐L‐tyrosine building blocks in the continuous‐flow method of Fmoc solid‐phase peptide synthesis. Different phosphate‐protecting groups have been applied.